We Can Change the Natural History of Type 2 Diabetes

We Can Change the Natural History of Type 2 Diabetes

As diabetes develops, we currently waste the first ∼10 years of the natural history. If we found prediabetes and early diabetes when they first presented and treated them more effectively, we could prevent or delay the progression of hyperglycemia and the development of complications. Evidence for this comes from trials where lifestyle change and/or glucose-lowering medications decreased progre...

(How) can we prevent type 2 diabetes?

The natural history of type 1A diabetes.

We can now predict the development of Type 1A (Immune Mediated) diabetes primarily through the determination of four biochemically characterized islet autoantibodies [insulin, GAD65, IA-2 (ICA512) and (Znt8)]. Prediction is possible because beta-cell destruction is chronically progressive and very slow in most, but not all individuals. We can also prevent type 1A diabetes in animal models and a...

Left ventricular assist device in Duchenne cardiomyopathy: can we change the natural history of cardiac disease?

End stage dilated cardiomyopathy (DCM) is currently one of the most challenging elements in the management of patients affected by Duchenne muscular dystrophy [1]. DCM is a complication of Duchenne muscular dystrophy, and leads to advanced heart failure and premature death [2,3]. Until the last decade, cardiomyopathy inDuchennemuscular dystrophy accounted for only 20% of deaths because respirat...

[Natural history of type 1 diabetes].

The natural history of autoimmune type 1 diabetes in children is associated with the appearance of islet autoantibodies early in life, which is influenced by genetic and environmental factors. Once islet autoantibodies have developed, the progression to diabetes in antibody-positive individuals is determined by the age of antibody appearance and by the magnitude of the autoimmunity, in turn rel...